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12.5. Case Study: Menopausal HRT

As covered in the previous video, men’s testosterone levels tend to decline over time as they age. Hormone levels in women decline as well, but it is a much more precipitous and rapid drop. This is the life event called menopause that every woman experiences. As with everything we have talked about in Early, aging is inevitable, but there are many things you can do to slow the process and cushion the decline. Menopausal hormone replacement therapy (HRT) can play a significant role in alleviating symptoms, improving quality of life, and optimizing health for many perimenopausal and postmenopausal women. Here we explain for whom HRT might be helpful, how HRT works, and the risks and benefits.

Additional Resources

Dive Deeper

Understanding the Endocrine System

Clearing the air on hormone replacement therapy

Why hormone replacement therapy is such an important topic | AMA #52 – Peter Attia

The onset of menopause: symptoms, blood tests, and when to consider HRT | AMA #52 – Peter Attia

Tests that may provide indications of perimenopause and their implications for fertility | AMA #52 – Peter Attia

The role of estrogen in menopausal HRT | AMA #52 – Peter Attia

Vasomotor symptoms: hormonal changes that cause hot flashes/night sweats, and HRT therapies that can help | AMA #52 – Peter Attia

The limited role of progesterone in HRT protocols | AMA #52 – Peter Attia

What is a “bioidentical” hormone? | AMA #52 – Peter Attia

Overview of the FDA-approved HRT formulations | AMA #52 – Peter Attia

Determining HRT dosing and considerations for perimenopausal women | AMA #52 – Peter Attia

Choosing the right HRT formulation: pros and cons | AMA #52 – Peter Attia

Examining the link between certain forms of estrogen and breast cancer | AMA #52 – Peter Attia

Changes in testosterone levels in women over time and why it matters | AMA #52 – Peter Attia

Recognizing low testosterone in women: common symptoms and diagnosis | AMA #52 – Peter Attia

Testosterone replacement therapy for women: options, considerations, and challenges | AMA #52 – Peter Attia

The long-term use of testosterone in women: examining the limited data | AMA #52 – Peter Attia

Controversial topic affecting all women—the role of hormone replacement therapy through menopause and beyond—the compelling case for long-term HRT and dispelling the myth that it causes breast cancer | Ep. #42 – Avrum Bluming, M.D. and Carol Tavris, Ph.D.

Hormone replacement therapy and the Women’s Health Initiative: re-examining the results, the link to breast cancer, and weighing the risk vs reward of HRT | Ep. #253 – JoAnn Manson, M.D.

Women’s sexual health: Why it matters, what can go wrong, and how to fix it | Ep. #259 – Sharon Parish, M.D.